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Kairos Health and Wellness

Semaglutide/ Tirzepatide

Functional Direct Primary Care

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FAQ

Semaglutide, a peptide medication utilized for weight loss, operates by mimicking the actions of a naturally occurring hormone known as GLP-1 (glucagon-like peptide-1). GLP-1, which is synthesized in the intestine and released in response to food consumption, offers several benefits conducive to weight reduction:

1. Appetite Suppression: Semaglutide aids in diminishing appetite by influencing the appetite control centers in the brain. This results in a decreased inclination for food intake and a sensation of satiety.

2. Slowed Gastric Emptying: It retards the process of stomach emptying, prolonging the sensation of fullness after a meal, thereby reducing food consumption.

3. Blood Sugar Regulation: It assists in managing blood sugar levels by prompting insulin release only when necessary, averting overeating caused by fluctuations in blood sugar levels.

4. Reduced Caloric Intake: By curbing hunger pangs and food cravings, it facilitates a decrease in calorie intake, which is pivotal for weight loss.

5. Enhanced Energy Expenditure: It may also augment energy expenditure, thereby contributing to weight loss efforts.

It is typically incorporated into a comprehensive weight management regimen, encompassing a reduced-calorie diet and increased physical activity. It should not be regarded as a standalone solution and necessitates prescription and supervision by a healthcare provider.

Semaglutide has been observed to influence hunger and appetite significantly. Numerous studies have indicated that this medication correlates with decreased hunger and food cravings, along with improved eating regulation. Moreover, it tends to diminish the preference for high-fat foods, thereby potentially aiding in weight loss efforts.

Unlike natural GLP-1, which is prone to enzymatic breakdown in the body, semaglutide is engineered to be more stable and enduring. This enhanced stability enables it to effectively suppress appetite and alleviate feelings of hunger, particularly following meals. As a result, semaglutide offers prolonged benefits in appetite control compared to natural GLP-1.

Neither medication is categorically “better,” as their efficacy can depend on individual factors. Both semaglutide and tirzepatide are newer type 2 diabetes medications sometimes prescribed for weight loss. They both show promise for helping manage weight. It appears that latter one may be more effective than former for certain purposes, specifically in terms of weight loss.

Depending on its use, semaglutide can be used for a long term in type 2 diabetes management and for a short term in weight management until the desired weight is achieved.
Semaglutide is not a quick fix for weight loss. Typically it takes several weeks to months of treatment with semaglutide to reach weight loss goals. Semaglutide is given for individuals struggling with obesity as part of a comprehensive weight management plan, which includes lifestyle changes like diet and exercise.
When taking semaglutide it is generally advisable to limit or avoid alcohol consumption. Although alcohol may not have a direct interaction with semaglutide, it may increase the risk of undesirable effects.

Semaglutide is a medication developed for two primary purposes: the treatment of type 2 diabetes and long-term weight management in obesity. It is available under several brand names, including Ozempic, Wegovy, and Rybelsus. Semaglutide is known for its efficacy in controlling blood sugar levels in diabetes patients and promoting significant weight loss in individuals with obesity.

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It works by mimicking the actions of natural GLP-1 hormones in the body. This results in increased insulin secretion, decreased glucagon production, slowed gastric emptying, and reduced appetite. These combined effects help regulate blood sugar levels and reduce body weight in obese individuals.

Semaglutide has shown promising results in aiding weight loss. After 68 weeks of use, half of the participants using semaglutide lost 15% of their body weight, and nearly a third lost 20%. The exact amount of weight you can lose with semaglutide can vary from person to person and depends on factors like diet, exercise, and individual response to the medication. 

To determine who is a good candidate for semaglutide, several factors should be considered based on the provided information:

  • BMI Criteria: Individuals with a body mass index (BMI) of 30 or above may be eligible to use semaglutide. If your BMI is 27 and you have one or more of the following health conditions related to weight, you might also qualify for semaglutide: type 2 diabetes, high blood pressure, and high cholesterol.
  • Weight Loss Goals: Semaglutide is often prescribed to individuals who are struggling with obesity and have not been able to achieve significant weight loss through diet and exercise alone.
  • Comfort with Injections: Since semaglutide is administered through self-injections, individuals who are comfortable with this mode of administration may be good candidates.
  • Consultation with a Healthcare Provider: The decision to use semaglutide should always be made in consultation with a healthcare provider. They can assess an individual’s specific health status, weight loss goals, and suitability for the medication.
Yes, semaglutide is FDA-approved for weight loss. Semaglutide, received FDA approval as a weight loss medication in 2021. This approval came as a significant development in the search for effective weight loss treatments. Semaglutide is used to aid in chronic weight management and can help individuals lose a substantial amount of body weight when used in combination with a proper diet and exercise regimen. Losing 5% to 10% of body weight through diet and exercise has been associated with improved health outcomes.

Typically the dose is increased gradually. For adults, the usual starting dose is 0.25 mg once a week for the first four weeks. After the initial four weeks: Increase the dose to 0.5 mg once a week. If necessary and under a doctor’s supervision: a further increase to 1.0 mg once a week may be considered for additional weight loss, up to 2.4 mg.

Semaglutide should only be used under the guidance of a healthcare provider. The specific dosage and treatment plan should be determined by a doctor based on individual health conditions and weight loss goals.

  • The recommended dosage of semaglutide for weight loss can vary depending on the specific medication and individual circumstances.
  • For adults: The typical starting dose of semaglutide for weight management is 0.25 mg once a week for four weeks. After the initial four weeks, the dosage is increased gradually up to 2.4mg. This dosage is administered as a subcutaneous injection (injection under the skin).

Follow the prescribed dosage and guidance provided by your healthcare provider when using semaglutide for weight loss. Adjustments to the dosage may be made based on individual needs and responses to the treatment. Semaglutide should be used as part of a comprehensive weight management plan that includes diet and exercise.

Semaglutide injection is administered once a week. It can be injected at any time of the day, with or without meals, and it is recommended to stay consistent with the day and time for the following weeks. Follow your healthcare provider’s recommended schedule and dosage.

Semaglutide is administered via subcutaneous injection, which means it is injected just beneath the skin. Common injection sites for semaglutide include the stomach, thigh, or arm. The specific injection site can vary based on individual preferences and healthcare provider recommendations. It’s important to rotate injection sites to prevent irritation or lumps under the skin.

As a medication, you can bring semaglutide through security at the airport, but they may ask to scan them separately. Because the pens contain liquid, they may need to go in a plastic bag. Be sure to keep your syringes, and needles in the same boxes that they came in with the original prescription label on them. Semaglutide may need to be refrigerated, depending on the specific medication you are using, and if it is opened or not. so you may need to pack it with ice. Ensure that you adhere to the storage guidelines provided with your medication. It’s advisable to carry a doctor’s prescription or a note explaining the medication’s necessity.

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and a Glucagon-like peptide-1 (GLP-1) receptor agonist. In other words, Tirzepatide targets 2 receptors whereas semaglutide targets one receptor (GLP-1). What does this mean clinically? Studies show that at max dosage patient using Tirzepatide saw 17.8% weight loss while patients using semaglutide saw a 12.4% weight loss. This is a 5.4% increase in effectiveness, which statistically speaking isn’t a lot. It’s impossible to predict the genetic variation in receptors a patient may have. Some patients do better on semaglutide and others on Tirzepatide. If the results are not what you are expecting on one medication, it might be worth switching from Semaglutide to Tirzepatide or vice versa to see if it produces a better effect. Tirzepatide generally costs a bit more, so that is also a factor to consider.
Semaglutide was approved in 2017 for diabetics and 2022 for medical weight loss. Similar GLP-1 agonists have been on the market for 20 years for use in diabetics. It is considered safe for long term weight loss usage and is FDA approved for this purpose.
Nausea, vomiting, "sour stomach", heart burn, constipation at higher dosages. Usually easily managed with an over the counter heartburn medication.
Contraindicated in those who have a personal or family history of thyroid cancer or a rare endocrine disorder called MEN2.

You inject once a week for 2-4 weeks. Your dosage will be adjusted every 4 weeks at telehealth visit. We will make adjustments till you reach your weight loss goal.

Your insulin receptors are on your muscles, so working out and exercise will not only help it work, but keep your cost down as it takes less Semaglutide to reach effectiveness.

Just like any other medication, if you do not change your lifestyle and diet, you will return to your former metabolism and could gain weight back. As long as you lose the weight at a slow steady rate and change your diet and lifestyle, it is unlikely you experience rebound weight gain. If you have PCOS or hormonal imbalance, we will address this as well. Keeping the testosterone level lower with PCOS maintenance medications will also help maintain weight loss.

Yes, we do! Just follow the instruction in the portal to connect your Fitbit account or you can integrate with Trainerize directly.

We have customized the Trainerize exercise and nutrition platform with custom exercise videos, fitness targets, body stats, tracking, rewards, support community, as well as daily personalized meal plans.

Yes, we do prescribe other medications to aid in weight loss. Your nurse practitioner will perform an evaluation to determine what medications are needed and if medications are right for you.

If you have insurance that covers your labs, imaging, and medications, you may use it, but you might find that our discounted prices are cheaper if you self-pay.
Kairos Health & Wellness Center offers both pay per visit and membership subscriptions. We are a cash pay only practice, meaning we do not accept insurance. Cash pay includes credit cards and debit cards. We also accept HSA/FSA cards.  We cannot accept patients with Medicaid or Medicare as we do not bill insurance.

It is often difficult to obtain insurance coverage, which is why many patients prefer to use FDA registered compounding pharmacies for an average cost of $200-$500 per month depending on your dosage.

Introduction

Semaglutide has emerged as a groundbreaking medication in the realm of weight loss and diabetes management. This guide delves into its multifaceted benefits, mechanisms, and common queries, offering a comprehensive overview of what you need to know about this medication.

What is Semaglutide?

Semaglutide is a GLP-1 receptor agonist, initially approved for treating type 2 diabetes. It mimics the incretin hormone, enhancing insulin secretion and regulating blood sugar levels. Recently, its efficacy in promoting weight loss has garnered significant attention, leading to its approval for weight management in adults with obesity or overweight conditions.

How Does Semaglutide Work?

Semaglutide works by stimulating insulin production, inhibiting glucagon release, and slowing gastric emptying. These actions collectively help manage blood sugar levels and reduce appetite, making it an effective treatment for both diabetes and weight loss.

Benefits

  • Weight Loss: Clinical trials have shown that Semaglutide can lead to significant weight reduction, with some participants losing up to 15% of their body weight.
  • Blood Sugar Control: It effectively lowers HbA1c levels, improving overall glycemic control in individuals with type 2 diabetes.
  • Cardiovascular Health: It has been associated with reduced cardiovascular risks, offering protection against heart diseases.
 

Administration and Dosage

This medication is administered via a once-weekly injection. The dosage may vary based on individual needs and medical guidance, typically starting at a lower dose to minimize side effects before gradually increasing.

Potential Side Effects

Like all medications, Semaglutide can cause side effects. Common ones include nausea, vomiting, diarrhea, and constipation. Most side effects are mild and tend to decrease over time. It’s crucial to consult a healthcare provider if severe or persistent symptoms occur.

Who Should Use Semaglutide?

It is suitable for adults with type 2 diabetes or those struggling with obesity. It is not recommended for individuals with a history of thyroid cancer, multiple endocrine neoplasia syndrome type 2, or those with a known hypersensitivity to the drug.

Conclusion

Semaglutide represents a significant advancement in the treatment of type 2 diabetes and obesity. Its dual benefits of improving blood sugar control and promoting substantial weight loss make it a valuable option for many individuals. As with any medication, it’s essential to consult with a healthcare provider to determine if  is the right choice for your health needs.